RNA Details
Disease Name
endomyocardial fibrosis
Tissue
heart
RNA Symbol
mir-25
RNA ID
RNA Type
miRNA
Alteration Pattern
down regulation
Species
mus musculus
Detection Methods
flow cytometery; qRT-PCR etc.
Target
HMGB1
Pathway
TGF-BETA SIGNALING PATHWAY
PubMed ID
Title
Protective effects of miR-25 against hypoxia/reoxygenation-induced fibrosis and apoptosis of H9c2 cells
Year
2016
Function
miR-25 against fibrosis and apoptosis human cells were due to direct targeting of HMGB1 through the downregulation of the TGF-beta1/smad3 signaling pathway.